3-Butyn-2-ol
- CAS number
- 2028-63-9
- Molecular formula
- C4H6O
- Molecular weight
- 70.09 g/mol
- Standard packing
- 1kg / 25kg / 100kg
CAS 2028-63-9, 3-Butyn-2-ol, enters the catalogue as a C4H6O alkyne with a molecular weight of 70.09.
An internal alkyne sets the geometry of the chain around it, which is usually why the entry appears in the route at all.
The formula C4H6O resolves to 4 carbons with one oxygen. With 4 carbons the molecule is small enough to be lost to evaporation during a work-up, so the step is usually run closed.
Where this entry sits in a route
3-Butyn-2-ol is the smallest chiral-adjacent alkyne alcohol: the secondary alcohol carries the stereocentre that most routes built on this entry are trying to set, and the terminal alkyne is the handle used to extend the chain. It is bought as the racemate and resolved downstream, or carried through achiral steps and resolved at the end.
What the analysis covers
Because the alcohol and the alkyne are both reactive, the specification checks the ketone that forms on oxidation and the allene that can form on prolonged storage. Neither appears on a headline assay value, which is why the impurity list is the useful document for this entry.
Handling and storage
The container is kept sealed and out of light. Alkynes are checked for the coupled diyne before use, because that is the impurity that builds on standing.
Ordering
Quoted from stock in 1kg / 25kg / 100kg, or made to order where the lot has run down. Either way the same release testing applies. Where a specification has to be met on paper before shipment, it is agreed in writing and the lot is qualified against it rather than against the catalogue text.
Quotation questions for this entry
Is 3-butyn-2-ol supplied as a single enantiomer?
The catalogue entry is the racemate. A single enantiomer can be quoted as a custom item, but it is a separate route and is priced accordingly.
Can the alcohol be protected without touching the alkyne?
Yes. Silyl protection is selective for the hydroxyl, and the alkyne survives it. The reverse order - protecting the alkyne first - is also possible with a TMS group.
What is the usual packing?
1 kg, 25 kg and 100 kg. Smaller samples are quoted separately for route scouting.
Which reactions is it normally bought for?
Sonogashira extension of the alkyne, esterification or oxidation of the secondary alcohol, and as a chiral pool starting point where the racemate is resolved later.
Other internal alkynes entries
| CAS | Compound | Formula | MW | Packing | Quote |
|---|---|---|---|---|---|
| 1073132-25-8 | (5Z)-5-Tetradecen-1-yne | C14H24 | 192.34 | 1kg / 25kg / 50kg | Request |
| 62992-46-5 | 2-(Pent-4-yn-1-yloxy)tetrahydro-2H-pyran | C10H16O2 | 168.23 | 1kg / 25kg / 100kg | Request |
| 7218-43-1 | 2-[2-(Prop-2-ynyloxy)ethoxy]ethan-1-ol | C7H12O3 | 144.17 | 1kg / 25kg / 100kg | Request |
| 1719-19-3 | 2-Methyl-4-phenyl-3-butyn-2-ol | C11H12O | 160.21 | 1kg / 25kg / 100kg | Request |
| 1423-60-5 | 3-Butyn-2-one | C4H4O | 68.07 | 1kg / 25kg / 100kg | Request |
| 40365-61-5 | 3-Butynyl tetrahydro-2H-pyran-2-yl ether | C9H14O2 | 154.21 | 1kg / 25kg / 100kg | Request |
| 3355-31-5 | 3-Chloro-1-phenyl-1-propyne | C9H7Cl | 150.60 | 1kg / 25kg / 100kg | Request |
| 628-33-1 | 3-Ethoxyprop-1-yne | C5H8O | 84.12 | 1kg / 25kg / 100kg | Request |
Ask about 3-Butyn-2-ol
The form below is pre-filled with this entry. Add the quantity, the specification you need to meet and the destination, and a written quotation follows within one business day.
| Entry | 3-Butyn-2-ol |
|---|---|
| CAS | 2028-63-9 |
| Typical lead time | Stock or 2–4 weeks |
| Documentation | COA, SDS, spec sheet |
Request a quotation
3-Butyn-2-ol (2028-63-9)