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3-(Trimethylsilyl)propargyl alcohol

CAS 5272-36-6 C6H12OSi 128.24 g/mol Catalogue item Boronic Acids & Coupling Reagents
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Structure of 3-(Trimethylsilyl)propargyl alcohol, CAS 5272-36-6
Structure · C6H12OSi
CAS number
5272-36-6
Molecular formula
C6H12OSi
Molecular weight
128.24 g/mol
Standard packing
1kg / 25kg / 100kg

Catalogued as CAS 5272-36-6, 3-(Trimethylsilyl)propargyl alcohol is a C6H12OSi alkyne carried in kilogram quantities.

Terminal alkynes also dimerise and oligomerise under the wrong conditions, so the copper and palladium loading of the coupling step is the thing to control. The protecting group is the reason the entry exists: it is carried through the steps that would otherwise attack the group underneath, and removed when that group is wanted.

The formula C6H12OSi resolves to 6 carbons with one oxygen and one silicon. With 6 carbons the molecule is small enough to be lost to evaporation during a work-up, so the step is usually run closed.

Handling and storage

The container is kept sealed and out of light. Alkynes are checked for the coupled diyne before use, because that is the impurity that builds on standing.

Ordering

Quoted from stock in 1kg / 25kg / 100kg, or made to order where the lot has run down. Either way the same release testing applies. The certificate states identity, assay and the analytical method used; a tighter limit than the catalogue entry can be written into the lot specification.

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Quotation

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Entry3-(Trimethylsilyl)propargyl alcohol
CAS5272-36-6
Typical lead timeStock or 2–4 weeks
DocumentationCOA, SDS, spec sheet

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3-(Trimethylsilyl)propargyl alcohol (5272-36-6)

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