(5-Chlorobenzofuran-2-yl)boronic acid

CAS 223576-64-5, (5-Chlorobenzofuran-2-yl)boronic acid, is catalogued as a boronic acid: C8H6BClO3, molecular weight 196.40.

The boronic acid is the coupling partner: Suzuki-Miyaura with an aryl or vinyl halide, Chan-Lam with an amine or phenol, and Petasis with an imine. The ring constrains the geometry of the fragment, so the entry is bought for the shape it imposes on the rest of the molecule rather than for a single reactive site.

The formula C8H6BClO3 resolves to 8 carbons with 3 oxygens, one boron and one chlorine. A 8-carbon chain sits between volatility and lipophilicity, which is the range most often used when a fragment has to stay in the organic phase without being waxy.

Handling and storage

Boronic acids can lose water to the anhydride on standing. The lot assay is corrected for that, and the container is kept sealed.

Ordering

The unit weights held are 1kg / 25kg / 100kg. A split shipment across two of those sizes is treated as one lot and one certificate. Identity is confirmed by NMR and MS at release, and the assay value belongs to the lot rather than to the catalogue entry.